Found 5 hits Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial' and Ligand = 'BDBM16109' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH) |
Bioorg Med Chem Lett 14: 55-8 (2003)
BindingDB Entry DOI: 10.7270/Q2XS5TS2 |
More data for this
Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description
Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053
BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this
Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053
BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this
Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description
Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053
BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this
Ligand-Target Pair | |
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