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Found 1 hit Enz. Inhib. hit(s) with Target = 'Dimer of Gag-Pol polyprotein [489-587]' and Ligand = 'BDBM494'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Gag-Pol polyprotein [489-587]


(Human immunodeficiency virus type 1)		BDBM494
PNG
((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(pyridin-4...)
Show SMILES CC(C)(C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1)Cc1ccncc1 |r|
Show InChI InChI=1S/C35H41N7O5/c1-35(2,3)41-34(47)42(21-24-15-17-37-18-16-24)22-30(43)28(19-23-9-5-4-6-10-23)39-33(46)29(20-31(36)44)40-32(45)27-14-13-25-11-7-8-12-26(25)38-27/h4-18,28-30,43H,19-22H2,1-3H3,(H2,36,44)(H,39,46)(H,40,45)(H,41,47)/t28-,29-,30+/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 19n/an/an/an/a6.425



Monsanto Corporate Research



Assay Description
IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...

J Med Chem 36: 288-91 (1993)


Article DOI: 10.1021/jm00054a014
BindingDB Entry DOI: 10.7270/Q2WW7FTF
More data for this
Ligand-Target Pair