Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dimer of Protein farnesyltransferase subunit beta' and Ligand = 'BDBM50103316'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103316 (4-(5-{[1-(4-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylam...) Show SMILES Clc1ccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)cc1 Show InChI InChI=1S/C23H22ClN5O/c24-20-7-5-19(6-8-20)14-28-10-9-22(23(28)30)27-13-21-12-26-16-29(21)15-18-3-1-17(11-25)2-4-18/h1-8,12,16,22,27H,9-10,13-15H2/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyl transferase using purified recombinant human enzyme				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103316 (4-(5-{[1-(4-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylam...) Show SMILES Clc1ccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)cc1 Show InChI InChI=1S/C23H22ClN5O/c24-20-7-5-19(6-8-20)14-28-10-9-22(23(28)30)27-13-21-12-26-16-29(21)15-18-3-1-17(11-25)2-4-18/h1-8,12,16,22,27H,9-10,13-15H2/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cells				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair