Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dimer of Protein farnesyltransferase subunit beta' and Ligand = 'BDBM50103362'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103362 (4-(5-{[1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidin-...) Show SMILES Brc1cncc(c1)C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C22H21BrN6O/c23-19-7-18(9-25-10-19)22(30)28-6-5-20(14-28)27-12-21-11-26-15-29(21)13-17-3-1-16(8-24)2-4-17/h1-4,7,9-11,15,20,27H,5-6,12-14H2/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyl transferase using purified recombinant human enzyme				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103362 (4-(5-{[1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidin-...) Show SMILES Brc1cncc(c1)C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C22H21BrN6O/c23-19-7-18(9-25-10-19)22(30)28-6-5-20(14-28)27-12-21-11-26-15-29(21)13-17-3-1-16(8-24)2-4-17/h1-4,7,9-11,15,20,27H,5-6,12-14H2/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cells				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair