Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dimer of Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM476706'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM476706 (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...) Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)c(O)cc34)cc(c2)C2CC2)C[C@@H](C)N1 Show InChI InChI=1S/C29H33ClN6O/c1-16-6-26-23(10-27(16)37)24(11-31-26)28-25(30)12-32-29(35-28)34-22-8-19(7-21(9-22)20-4-5-20)15-36-13-17(2)33-18(3)14-36/h6-12,17-18,20,31,33,37H,4-5,13-15H2,1-3H3,(H,32,34,35)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VX0KQ4
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM476706 (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...) Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)c(O)cc34)cc(c2)C2CC2)C[C@@H](C)N1 Show InChI InChI=1S/C29H33ClN6O/c1-16-6-26-23(10-27(16)37)24(11-31-26)28-25(30)12-32-29(35-28)34-22-8-19(7-21(9-22)20-4-5-20)15-36-13-17(2)33-18(3)14-36/h6-12,17-18,20,31,33,37H,4-5,13-15H2,1-3H3,(H,32,34,35)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
HANMI PHARM. CO.. LTD. US Patent					Assay Description The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...				US Patent US10870639 (2020) BindingDB Entry DOI: 10.7270/Q20G3P70
					More data for this Ligand-Target Pair