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Found 1 hit Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 4' and Ligand = 'BDBM50349378'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50349378
PNG
(CHEMBL1808466)
Show SMILES CNC(=O)COc1ccc2nc(CC(C)C)c(CN)c(-c3ccc(C)cc3)c2c1
Show InChI InChI=1S/C24H29N3O2/c1-15(2)11-22-20(13-25)24(17-7-5-16(3)6-8-17)19-12-18(9-10-21(19)27-22)29-14-23(28)26-4/h5-10,12,15H,11,13-14,25H2,1-4H3,(H,26,28)
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n/an/a 52n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysis

Bioorg Med Chem 19: 4482-98 (2011)


Article DOI: 10.1016/j.bmc.2011.06.032
BindingDB Entry DOI: 10.7270/Q2P26ZGN
More data for this
Ligand-Target Pair