Found 7 hits Enz. Inhib. hit(s) with Target = 'Disintegrin and metalloproteinase domain-containing protein 17' and Ligand = 'BDBM50441214' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 825 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50441214
![PNG](/data/jpeg/tenK5044/BindingDB_50441214.png) (CHEMBL2431026)Show SMILES ONC(=O)[C@@H](CCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1 |r| Show InChI InChI=1S/C25H25Br2N3O7S/c26-19-12-18(13-20(27)14-19)16-36-21-6-8-22(9-7-21)38(34,35)30-23(24(31)29-33)10-11-28-25(32)37-15-17-4-2-1-3-5-17/h1-9,12-14,23,30,33H,10-11,15-16H2,(H,28,32)(H,29,31)/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured... |
J Med Chem 56: 8089-103 (2013)
Article DOI: 10.1021/jm4011753 BindingDB Entry DOI: 10.7270/Q2DR2WZ0 |
More data for this Ligand-Target Pair | |