Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human)) | BDBM50335827![]() ((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assay | J Med Chem 54: 495-509 (2011) Article DOI: 10.1021/jm100842v BindingDB Entry DOI: 10.7270/Q2RR1ZHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human)) | BDBM50335827![]() ((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assay | J Med Chem 54: 495-509 (2011) Article DOI: 10.1021/jm100842v BindingDB Entry DOI: 10.7270/Q2RR1ZHQ | |||||||||||
More data for this Ligand-Target Pair |