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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B' and Ligand = 'BDBM462269'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM462269
PNG
(US10766893, Example 22b)
Show SMILES CCOc1nnccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H26N8O/c1-6-30-21-16(7-8-23-27-21)17-10-18(22-11-15-9-13(4)25-26-15)20-19(24-17)14(5)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,24)(H,25,26)
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MMDB

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US Patent
n/an/a 0.400n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...


US Patent US10766893 (2020)


BindingDB Entry DOI: 10.7270/Q2ZP495P
More data for this
Ligand-Target Pair