BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase CLK2' and Ligand = 'BDBM50335638'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CLK2 incubated for 2 hrs				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00131 BindingDB Entry DOI: 10.7270/Q2ZS319T
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Inhibition of CLK2 (unknown origin)				Bioorg Med Chem 26: 3016-3020 (2018) Article DOI: 10.1016/j.bmc.2018.05.011 BindingDB Entry DOI: 10.7270/Q2X3513P
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assay				J Med Chem 62: 1803-1816 (2019) Article DOI: 10.1021/acs.jmedchem.8b01766 BindingDB Entry DOI: 10.7270/Q2NS0ZCZ
Saarland University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lyon Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...				J Med Chem 62: 1817-1836 (2019) Article DOI: 10.1021/acs.jmedchem.8b01765 BindingDB Entry DOI: 10.7270/Q2SJ1Q27
Universit£ de Lyon Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lyon Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...				J Med Chem 62: 1817-1836 (2019) Article DOI: 10.1021/acs.jmedchem.8b01765 BindingDB Entry DOI: 10.7270/Q2SJ1Q27
Universit£ de Lyon Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assay				J Med Chem 62: 1803-1816 (2019) Article DOI: 10.1021/acs.jmedchem.8b01766 BindingDB Entry DOI: 10.7270/Q2NS0ZCZ
Saarland University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50335638 (5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116914 BindingDB Entry DOI: 10.7270/Q2HH6Q1V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)