Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM413450 (7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PDB UniChem | US Patent | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB US Patent | Assay Description The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific... | US Patent US10407446 (2019) BindingDB Entry DOI: 10.7270/Q2MS3W4T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM413450 (7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PDB UniChem | US Patent | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitory activity of compounds against TTK was determined in a LanthaScreenŽ Eu Kinase Binding assay run by ThermoFisher Scientific as part of ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2V98C76 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM413450 (7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PDB UniChem | Article PubMed | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human full-length GST-tagged TTK expressed in baculovirus expression system measur... | J Med Chem 63: 3461-3471 (2020) Article DOI: 10.1021/acs.jmedchem.9b01684 BindingDB Entry DOI: 10.7270/Q22Z18Z4 | |||||||||||
More data for this Ligand-Target Pair |