Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM50567048 (CHEMBL4848696) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01115 BindingDB Entry DOI: 10.7270/Q2BV7MDT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM50567048 (CHEMBL4848696) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01115 BindingDB Entry DOI: 10.7270/Q2BV7MDT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM50567048 (CHEMBL4848696) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01115 BindingDB Entry DOI: 10.7270/Q2BV7MDT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |