BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dual specificity tyrosine-phosphorylation-regulated kinase 1A' and Ligand = 'BDBM8127'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM8127 (N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...) Show SMILES CN(c1ccccc1)c1nccc(n1)-c1cnn2ncccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01115 BindingDB Entry DOI: 10.7270/Q2BV7MDT
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM8127 (N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...) Show SMILES CN(c1ccccc1)c1nccc(n1)-c1cnn2ncccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
University of Sussex Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal Hex-tagged DYRK1A (127 to 485 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by ...				ACS Med Chem Lett 11: 1620-1626 (2020) Article DOI: 10.1021/acsmedchemlett.0c00279 BindingDB Entry DOI: 10.7270/Q2ZW1QGM
University of Sussex Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)