Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50279230'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50279230 (CHEMBL4170591) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1C1N(Cc2ccc(Cl)c(Cl)c2)C(=O)CCCCCCCCCCCCCNC1=O Show InChI InChI=1S/C32H38Cl3N3O4/c33-22-14-15-23-26(19-22)37-29(32(41)42)28(23)30-31(40)36-17-11-9-7-5-3-1-2-4-6-8-10-12-27(39)38(30)20-21-13-16-24(34)25(35)18-21/h13-16,18-19,30,37H,1-12,17,20H2,(H,36,40)(H,41,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from recombinant human N-terminal MDM2 (1 to 118 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL a...				ACS Med Chem Lett 8: 1025-1030 (2017) Article DOI: 10.1021/acsmedchemlett.7b00219 BindingDB Entry DOI: 10.7270/Q2TQ6424
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