Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50499317'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50499317 (CHEMBL3735043) Show SMILES Clc1ccc(Cn2c(-c3c([nH]c4cc(Cl)ccc34)C(=O)NCCN3CCOCC3)c(-c3ccccc3)c3ccccc23)cc1 |(10.13,5.08,;9.03,4.52,;8.95,2.98,;7.58,2.28,;6.29,3.11,;4.92,2.41,;3.63,3.25,;2.23,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-3.45,-1.38,;-2.38,.77,;-1.03,1.55,;.3,.77,;4.2,.03,;4.8,1.11,;4.98,-1.29,;6.52,-1.28,;7.3,-2.61,;8.84,-2.59,;9.63,-3.92,;11.17,-3.9,;11.92,-2.56,;11.14,-1.23,;9.6,-1.25,;1.23,3.86,;-.3,3.74,;-1.27,4.93,;-2.79,4.69,;-3.34,3.25,;-2.37,2.05,;-.85,2.3,;2.04,5.16,;1.61,6.64,;2.7,7.75,;4.19,7.37,;4.62,5.87,;3.53,4.78,;6.37,4.65,;7.74,5.35,)| Show InChI InChI=1S/C36H32Cl2N4O2/c37-26-12-10-24(11-13-26)23-42-31-9-5-4-8-29(31)32(25-6-2-1-3-7-25)35(42)33-28-15-14-27(38)22-30(28)40-34(33)36(43)39-16-17-41-18-20-44-21-19-41/h1-15,22,40H,16-21,23H2,(H,39,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Competition binding affinity to MDM2 (unknown origin) using p53 mimicking peptide TSFAEYWNLLSP after 30 mins by fluorescence polarization assay				Bioorg Med Chem Lett 25: 5661-6 (2015) Article DOI: 10.1016/j.bmcl.2015.11.019 BindingDB Entry DOI: 10.7270/Q2WM1HF9
					More data for this Ligand-Target Pair