Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50515647'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50515647 (CHEMBL4468113) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(CCc1ccccc1)C=O)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C28H26ClN3O4/c29-21-11-12-22-23(17-21)31-25(28(35)36)24(22)26(27(34)30-15-13-19-7-3-1-4-8-19)32(18-33)16-14-20-9-5-2-6-10-20/h1-12,17-18,26,31H,13-16H2,(H,30,34)(H,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant N-terminal domain of MDM2 (1 to 118 residues) expressed in Escherichia coli BL21 (DE3) cell...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
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