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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [1-188]' and Ligand = 'BDBM215341'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM215341
PNG
(US9296736, 309 | US9593129, Example 309)
Show SMILES CC[C@@H](CS(=O)(=O)C1CCOCC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H35Cl2NO6S/c1-3-23(18-39(36,37)24-11-13-38-14-12-24)32-27(19-7-9-21(30)10-8-19)25(20-5-4-6-22(31)15-20)16-29(2,28(32)35)17-26(33)34/h4-10,15,23-25,27H,3,11-14,16-18H2,1-2H3,(H,33,34)/t23-,25+,27+,29+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...

US Patent US9593129 (2017)


BindingDB Entry DOI: 10.7270/Q20P1232
More data for this
Ligand-Target Pair