BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Egl nine homolog 1' and Ligand = 'BDBM118339'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Egl nine homolog 1 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00415 BindingDB Entry DOI: 10.7270/Q2CN7810
TBA					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc...				Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PHD2 (unknown origin) using biotinylated HIF-1alpha (558 to 574 residues) as substrate after 1 hr by homogeneous time-resolved fluoresc...				ACS Med Chem Lett 6: 1236-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00394 BindingDB Entry DOI: 10.7270/Q2RB76G9
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Cadila Healthcare Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human HIF-PHD2 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL as substrate preincuba...				J Med Chem 61: 6964-6982 (2018) Article DOI: 10.1021/acs.jmedchem.7b01686 BindingDB Entry DOI: 10.7270/Q2H70JC7
Cadila Healthcare Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	876	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...				ACS Med Chem Lett 6: 1236-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00394 BindingDB Entry DOI: 10.7270/Q2RB76G9
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair