Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human)) | BDBM372964 (US10597366, Compound 8 | US9896418, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. Curated by ChEMBL | Assay Description Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assay | J Med Chem 61: 9691-9721 (2018) Article DOI: 10.1021/acs.jmedchem.8b01196 BindingDB Entry DOI: 10.7270/Q2H997RJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human)) | BDBM372964 (US10597366, Compound 8 | US9896418, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. US Patent | Assay Description HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1... | US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human)) | BDBM372964 (US10597366, Compound 8 | US9896418, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. Curated by ChEMBL | Assay Description Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assay | J Med Chem 61: 9691-9721 (2018) Article DOI: 10.1021/acs.jmedchem.8b01196 BindingDB Entry DOI: 10.7270/Q2H997RJ | |||||||||||
More data for this Ligand-Target Pair |