Found 2 hits Enz. Inhib. hit(s) with Target = 'Endothelial lipase' and Ligand = 'BDBM50506738' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial lipase
(Homo sapiens (Human)) | BDBM50506738
(CHEMBL4558644)Show SMILES Nc1c([nH]c(=O)[nH]c1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccc(OCc2ccccc2)cc1 |r,wU:12.12,15.19,(34.47,-21.76,;34.48,-23.3,;33.15,-24.08,;33.16,-25.62,;34.48,-26.38,;34.48,-27.92,;35.82,-25.62,;35.82,-24.08,;37.15,-23.3,;31.82,-23.32,;31.81,-21.78,;30.49,-24.09,;29.15,-23.33,;27.82,-24.11,;26.49,-23.33,;26.49,-21.79,;27.82,-21.03,;29.15,-21.79,;25.16,-21.03,;25.17,-19.49,;23.83,-18.71,;22.5,-19.49,;21.16,-18.72,;21.16,-17.18,;19.83,-16.41,;19.83,-14.88,;18.5,-14.1,;17.17,-14.88,;17.17,-16.43,;18.51,-17.18,;22.5,-21.04,;23.84,-21.79,)| Show InChI InChI=1S/C24H26N4O4/c25-20-21(27-24(31)28-22(20)29)23(30)26-18-10-6-16(7-11-18)17-8-12-19(13-9-17)32-14-15-4-2-1-3-5-15/h1-5,8-9,12-13,16,18H,6-7,10-11,14,25H2,(H,26,30)(H2,27,28,29,31)/t16-,18+ | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human endothelial lipase expressed in African green monkey COS7 cells using HDL as substrate pretreated for 10 mins followe... |
Bioorg Med Chem Lett 28: 3721-3725 (2018)
Article DOI: 10.1016/j.bmcl.2018.10.022
BindingDB Entry DOI: 10.7270/Q2JS9TQ8 |
More data for this
Ligand-Target Pair | |
Endothelial lipase
(Homo sapiens (Human)) | BDBM50506738
(CHEMBL4558644)Show SMILES Nc1c([nH]c(=O)[nH]c1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccc(OCc2ccccc2)cc1 |r,wU:12.12,15.19,(34.47,-21.76,;34.48,-23.3,;33.15,-24.08,;33.16,-25.62,;34.48,-26.38,;34.48,-27.92,;35.82,-25.62,;35.82,-24.08,;37.15,-23.3,;31.82,-23.32,;31.81,-21.78,;30.49,-24.09,;29.15,-23.33,;27.82,-24.11,;26.49,-23.33,;26.49,-21.79,;27.82,-21.03,;29.15,-21.79,;25.16,-21.03,;25.17,-19.49,;23.83,-18.71,;22.5,-19.49,;21.16,-18.72,;21.16,-17.18,;19.83,-16.41,;19.83,-14.88,;18.5,-14.1,;17.17,-14.88,;17.17,-16.43,;18.51,-17.18,;22.5,-21.04,;23.84,-21.79,)| Show InChI InChI=1S/C24H26N4O4/c25-20-21(27-24(31)28-22(20)29)23(30)26-18-10-6-16(7-11-18)17-8-12-19(13-9-17)32-14-15-4-2-1-3-5-15/h1-5,8-9,12-13,16,18H,6-7,10-11,14,25H2,(H,26,30)(H2,27,28,29,31)/t16-,18+ | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of endothelial lipase (unknown origin) using D31-POPC-HDL as substrate after 2 hrs in presence of human serum by LC/MS analysis |
Bioorg Med Chem Lett 28: 3721-3725 (2018)
Article DOI: 10.1016/j.bmcl.2018.10.022
BindingDB Entry DOI: 10.7270/Q2JS9TQ8 |
More data for this
Ligand-Target Pair | |
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