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Found 1 hit Enz. Inhib. hit(s) with Target = 'Endothelin-converting enzyme 1' and Ligand = 'BDBM50046820'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin-converting enzyme 1


(Rattus norvegicus (Rat))		BDBM50046820
PNG
(4-Methyl-piperazine-1-carboxylic acid {2-cyclohexy...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCN(C)CC1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)[C@@H](O)[C@@H](O)CC(C)C
Show InChI InChI=1S/C39H61N5O5/c1-6-27(4)35(42-37(47)33(24-28-12-8-7-9-13-28)41-39(49)44-20-18-43(5)19-21-44)38(48)40-32(36(46)34(45)22-26(2)3)25-29-16-17-30-14-10-11-15-31(30)23-29/h10-11,14-17,23,26-28,32-36,45-46H,6-9,12-13,18-22,24-25H2,1-5H3,(H,40,48)(H,41,49)(H,42,47)/t27?,32-,33-,34-,35-,36+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of conversion of big endothelial-1 (Big ET-1) to ET-1 by endothelin converting enzyme(ECE) in rat lung membrane.

J Med Chem 36: 468-78 (1993)


BindingDB Entry DOI: 10.7270/Q2PC331F
More data for this
Ligand-Target Pair