Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Ephrin type-B receptor 4' and Ligand = 'BDBM50299226'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50299226 (8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...) Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay				J Med Chem 52: 6433-46 (2009) Article DOI: 10.1021/jm9009444 BindingDB Entry DOI: 10.7270/Q2BZ663G
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50299226 (8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...) Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) transfected in CHO cells using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50299226 (8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...) Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) transfected in CHO cells using [gamma-33P]ATP by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50299226 (8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...) Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 by [gamma33-P]ATP based assay				J Med Chem 52: 6433-46 (2009) Article DOI: 10.1021/jm9009444 BindingDB Entry DOI: 10.7270/Q2BZ663G
					More data for this Ligand-Target Pair