Found 12 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM3532' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
| Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... |
J Med Chem 39: 267-76 (1996)
Article DOI: 10.1021/jm9503613 BindingDB Entry DOI: 10.7270/Q25T3HPR |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 0.316 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of EGFR |
J Med Chem 51: 1179-88 (2008)
Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Lawrence Berkeley National Laboratory
Curated by ChEMBL
| Assay Description Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cells |
J Med Chem 48: 7445-56 (2005)
Article DOI: 10.1021/jm050607w BindingDB Entry DOI: 10.7270/Q26D5TT6 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 1.26 | n/a | n/a | n/a | n/a | n/a | n/a |
Lawrence Berkeley National Laboratory
Curated by ChEMBL
| Assay Description Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranes |
J Med Chem 48: 7445-56 (2005)
Article DOI: 10.1021/jm050607w BindingDB Entry DOI: 10.7270/Q26D5TT6 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of EGFR (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113766 BindingDB Entry DOI: 10.7270/Q2F47T0M |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00302 BindingDB Entry DOI: 10.7270/Q20Z779V |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007 BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS Limited
Curated by ChEMBL
| Assay Description Inhibition of Epidermal growth factor receptor |
J Med Chem 42: 1018-26 (1999)
Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation. |
Bioorg Med Chem Lett 7: 417-420 (1997)
Article DOI: 10.1016/S0960-894X(97)00034-6 BindingDB Entry DOI: 10.7270/Q2J966VN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Mus musculus) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS Limited
Curated by ChEMBL
| Assay Description Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation |
J Med Chem 42: 1018-26 (1999)
Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS Limited
Curated by ChEMBL
| Assay Description Inhibition of Epidermal growth factor receptor-dependent phosphorylation |
J Med Chem 42: 1018-26 (1999)
Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
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| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Hebrew University of Jerusalem
| Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. |
Bioorg Med Chem 4: 1203-7 (1996)
Article DOI: 10.1016/0968-0896(96)00107-1 BindingDB Entry DOI: 10.7270/Q2BC3WR8 |
More data for this Ligand-Target Pair | |