Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [T790M,L858R]' and Ligand = 'BDBM318883'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318883 (N-(2-cyano-3-(2-((4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4C#N)c3n2)cc1 Show InChI InChI=1S/C29H27N7O/c1-3-27(37)33-26-9-5-7-23(25(26)18-30)24-8-4-6-20-19-31-29(34-28(20)24)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,19H,1,14-17H2,2H3,(H,33,37)(H,31,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318883 (N-(2-cyano-3-(2-((4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4C#N)c3n2)cc1 Show InChI InChI=1S/C29H27N7O/c1-3-27(37)33-26-9-5-7-23(25(26)18-30)24-8-4-6-20-19-31-29(34-28(20)24)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,19H,1,14-17H2,2H3,(H,33,37)(H,31,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description EGFR (T790M)(L858R):The 2×EGFR (ErbB1) T790M L858R/Tyr 04 mixture is prepared in 50 mM HEPES pH 6.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, 0.02% NaN...				Citation and Details BindingDB Entry DOI: 10.7270/Q2571G7W
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318883 (N-(2-cyano-3-(2-((4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4C#N)c3n2)cc1 Show InChI InChI=1S/C29H27N7O/c1-3-27(37)33-26-9-5-7-23(25(26)18-30)24-8-4-6-20-19-31-29(34-28(20)24)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,19H,1,14-17H2,2H3,(H,33,37)(H,31,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020) BindingDB Entry DOI: 10.7270/Q2TB19XQ
					More data for this Ligand-Target Pair