Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inverse agonist activity at ERRgamma (unknown origin) by luciferase reporter gene assay | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112501 BindingDB Entry DOI: 10.7270/Q2ZK5MB0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa... | Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed a... | J Med Chem 62: 1837-1858 (2019) Article DOI: 10.1021/acs.jmedchem.8b01296 BindingDB Entry DOI: 10.7270/Q2BK1GVZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed a... | J Med Chem 62: 1837-1858 (2019) Article DOI: 10.1021/acs.jmedchem.8b01296 BindingDB Entry DOI: 10.7270/Q2BK1GVZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GSK | Assay Description Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand... | Bioorg Med Chem Lett 16: 821-4 (2006) Article DOI: 10.1016/j.bmcl.2005.11.030 BindingDB Entry DOI: 10.7270/Q2WW7FZ7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB US Patent | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION US Patent | Assay Description ERRγ: The arylethene derivative of the present invention was sequentially added to a 384 well plate from a concentration of 10 μM to a fina... | US Patent US10934303 (2021) BindingDB Entry DOI: 10.7270/Q2V40ZBT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB US Patent | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In an ERR alpha binding assay, GST-bound ERR alpha LBD was used, and all experiments other than that was the same as the ERR gamma binding assay.In a... | Citation and Details BindingDB Entry DOI: 10.7270/Q25D8W20 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to ERRgamma (unknown origin) by TR-FRET assay | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112501 BindingDB Entry DOI: 10.7270/Q2ZK5MB0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | J Med Chem 62: 1837-1858 (2019) Article DOI: 10.1021/acs.jmedchem.8b01296 BindingDB Entry DOI: 10.7270/Q2BK1GVZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay | Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL | Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | J Med Chem 62: 1837-1858 (2019) Article DOI: 10.1021/acs.jmedchem.8b01296 BindingDB Entry DOI: 10.7270/Q2BK1GVZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen-related receptor gamma (Homo sapiens (Human)) | BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Beckman Research Institute Curated by ChEMBL | Assay Description Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a... | Bioorg Med Chem 25: 1585-1599 (2017) Article DOI: 10.1016/j.bmc.2017.01.019 BindingDB Entry DOI: 10.7270/Q2DF6TFV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |