Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 2-alpha kinase 3' and Ligand = 'BDBM103847'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103847 (US9695165, 30 | US9695165, 31) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
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