Found 3 hits Enz. Inhib. hit(s) with Target = 'Fatty-acid amide hydrolase 1' and Ligand = 'BDBM50350557' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Reversible inhibition of human FAAH |
Bioorg Med Chem Lett 21: 4674-85 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.096 BindingDB Entry DOI: 10.7270/Q2W959JK |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FAAH |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.111953 BindingDB Entry DOI: 10.7270/Q2BC436Z |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064 BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this Ligand-Target Pair | |