BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Fatty-acid amide hydrolase 1 [30-579]' and Ligand = 'BDBM50307794'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50307794 (2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat cerebellum membranes pre-incubated for 10 mins before addition of [3H]AEA substrate in presence of ethyl alc...				J Med Chem 55: 8807-26 (2012) Article DOI: 10.1021/jm3011146 BindingDB Entry DOI: 10.7270/Q2G161ZJ
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50307794 (2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	7.0	4
Ume� University					Assay Description Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....				J Enzyme Inhib Med Chem 28: 172-82 (2013) Article DOI: 10.3109/14756366.2011.643304 BindingDB Entry DOI: 10.7270/Q2BG2MWD
Ume� University					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50307794 (2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	7.0	4
Ume� University					Assay Description Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....				J Enzyme Inhib Med Chem 28: 172-82 (2013) Article DOI: 10.3109/14756366.2011.643304 BindingDB Entry DOI: 10.7270/Q2BG2MWD
Ume� University					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50307794 (2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Cagliari Curated by ChEMBL					Assay Description Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy				J Med Chem 53: 2286-98 (2010) Article DOI: 10.1021/jm901891p BindingDB Entry DOI: 10.7270/Q2833S4K
University of Cagliari Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50307794 (2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...				J Med Chem 55: 8807-26 (2012) Article DOI: 10.1021/jm3011146 BindingDB Entry DOI: 10.7270/Q2G161ZJ
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair