Found 4 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM286998' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286998
![PNG](/data/jpeg/tenK28/BindingDB_286998.png) (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286998
![PNG](/data/jpeg/tenK28/BindingDB_286998.png) (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286998
![PNG](/data/jpeg/tenK28/BindingDB_286998.png) (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286998
![PNG](/data/jpeg/tenK28/BindingDB_286998.png) (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |