Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287039'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287039 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(1.33,8.47,;2.67,7.7,;2.67,6.16,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;1.33,3.85,;1.33,5.39,;,6.16,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;,1.54,;1.33,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287039 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(1.33,8.47,;2.67,7.7,;2.67,6.16,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;1.33,3.85,;1.33,5.39,;,6.16,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;,1.54,;1.33,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB850W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287039 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(1.33,8.47,;2.67,7.7,;2.67,6.16,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;1.33,3.85,;1.33,5.39,;,6.16,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;,1.54,;1.33,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287039 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(1.33,8.47,;2.67,7.7,;2.67,6.16,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;1.33,3.85,;1.33,5.39,;,6.16,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;,1.54,;1.33,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair