Found 4 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287511' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287511
![PNG](/data/jpeg/tenK28/BindingDB_287511.png) (8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...)Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C |(-1.61,-6,;-1.61,-4.46,;-.28,-3.69,;-.28,-2.15,;-1.61,-1.38,;-1.61,.16,;-2.94,.93,;-4.28,.16,;-5.61,.93,;-6.94,.16,;-6.94,-1.38,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287511
![PNG](/data/jpeg/tenK28/BindingDB_287511.png) (8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...)Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C |(-1.61,-6,;-1.61,-4.46,;-.28,-3.69,;-.28,-2.15,;-1.61,-1.38,;-1.61,.16,;-2.94,.93,;-4.28,.16,;-5.61,.93,;-6.94,.16,;-6.94,-1.38,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287511
![PNG](/data/jpeg/tenK28/BindingDB_287511.png) (8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...)Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C |(-1.61,-6,;-1.61,-4.46,;-.28,-3.69,;-.28,-2.15,;-1.61,-1.38,;-1.61,.16,;-2.94,.93,;-4.28,.16,;-5.61,.93,;-6.94,.16,;-6.94,-1.38,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287511
![PNG](/data/jpeg/tenK28/BindingDB_287511.png) (8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...)Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C |(-1.61,-6,;-1.61,-4.46,;-.28,-3.69,;-.28,-2.15,;-1.61,-1.38,;-1.61,.16,;-2.94,.93,;-4.28,.16,;-5.61,.93,;-6.94,.16,;-6.94,-1.38,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |