Found 3 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287514' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287514
![PNG](/data/jpeg/tenK28/BindingDB_287514.png) ((R)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...)Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1 |r,wD:24.24,(-6.67,-.86,;-6.67,.68,;-5.33,1.45,;-5.33,2.99,;-4,3.76,;-2.67,2.99,;-1.33,3.76,;,2.99,;1.33,3.76,;1.33,5.3,;,6.07,;2.67,6.07,;2.67,7.61,;4,8.38,;4,5.3,;4,3.76,;5.33,2.99,;6.67,3.76,;2.67,2.99,;2.67,1.45,;,1.45,;1.33,.68,;-1.33,.68,;-1.33,-.86,;-2.67,-1.63,;-4.13,-1.16,;-5.04,-2.4,;-4.13,-3.65,;-2.67,-3.17,;-1.58,-4.26,;-1.58,-5.8,;-.04,-5.8,;-.04,-4.26,;1.05,-6.89,;.65,-8.38,;2.54,-6.49,;3.63,-7.58,;-2.67,1.45,;-4,.68,)| Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287514
![PNG](/data/jpeg/tenK28/BindingDB_287514.png) ((R)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...)Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1 |r,wD:24.24,(-6.67,-.86,;-6.67,.68,;-5.33,1.45,;-5.33,2.99,;-4,3.76,;-2.67,2.99,;-1.33,3.76,;,2.99,;1.33,3.76,;1.33,5.3,;,6.07,;2.67,6.07,;2.67,7.61,;4,8.38,;4,5.3,;4,3.76,;5.33,2.99,;6.67,3.76,;2.67,2.99,;2.67,1.45,;,1.45,;1.33,.68,;-1.33,.68,;-1.33,-.86,;-2.67,-1.63,;-4.13,-1.16,;-5.04,-2.4,;-4.13,-3.65,;-2.67,-3.17,;-1.58,-4.26,;-1.58,-5.8,;-.04,-5.8,;-.04,-4.26,;1.05,-6.89,;.65,-8.38,;2.54,-6.49,;3.63,-7.58,;-2.67,1.45,;-4,.68,)| Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287514
![PNG](/data/jpeg/tenK28/BindingDB_287514.png) ((R)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...)Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1 |r,wD:24.24,(-6.67,-.86,;-6.67,.68,;-5.33,1.45,;-5.33,2.99,;-4,3.76,;-2.67,2.99,;-1.33,3.76,;,2.99,;1.33,3.76,;1.33,5.3,;,6.07,;2.67,6.07,;2.67,7.61,;4,8.38,;4,5.3,;4,3.76,;5.33,2.99,;6.67,3.76,;2.67,2.99,;2.67,1.45,;,1.45,;1.33,.68,;-1.33,.68,;-1.33,-.86,;-2.67,-1.63,;-4.13,-1.16,;-5.04,-2.4,;-4.13,-3.65,;-2.67,-3.17,;-1.58,-4.26,;-1.58,-5.8,;-.04,-5.8,;-.04,-4.26,;1.05,-6.89,;.65,-8.38,;2.54,-6.49,;3.63,-7.58,;-2.67,1.45,;-4,.68,)| Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |