Found 4 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287531' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287531
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)Show SMILES CCN1CCC(CNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-9.61,-6,;-9.61,-4.46,;-8.28,-3.69,;-6.94,-4.46,;-5.61,-3.69,;-5.61,-2.15,;-4.28,-1.38,;-4.28,.16,;-2.94,.93,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;2.39,2.47,;3.72,3.24,;3.72,4.78,;2.39,5.55,;5.06,5.55,;5.06,7.09,;6.39,7.86,;6.39,4.78,;6.39,3.24,;7.73,2.47,;9.06,3.24,;5.06,2.47,;5.06,.93,;2.39,.93,;3.72,.16,;1.06,.16,;1.06,-1.38,;2.39,-2.15,;2.39,-3.69,;3.72,-4.46,;4.12,-5.95,;5.61,-5.55,;5.21,-4.06,;6.94,-6.32,;6.94,-7.86,;8.28,-5.55,;9.61,-6.32,;-.28,.93,;-1.61,.16,;-6.94,-1.38,;-8.28,-2.15,)| Show InChI InChI=1S/C31H38Cl2N6O5/c1-5-25(40)38-17-21(18-38)44-12-11-39-29-20(16-35-31(36-29)34-15-19-7-9-37(6-2)10-8-19)13-22(30(39)41)26-27(32)23(42-3)14-24(43-4)28(26)33/h5,13-14,16,19,21H,1,6-12,15,17-18H2,2-4H3,(H,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287531
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)Show SMILES CCN1CCC(CNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-9.61,-6,;-9.61,-4.46,;-8.28,-3.69,;-6.94,-4.46,;-5.61,-3.69,;-5.61,-2.15,;-4.28,-1.38,;-4.28,.16,;-2.94,.93,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;2.39,2.47,;3.72,3.24,;3.72,4.78,;2.39,5.55,;5.06,5.55,;5.06,7.09,;6.39,7.86,;6.39,4.78,;6.39,3.24,;7.73,2.47,;9.06,3.24,;5.06,2.47,;5.06,.93,;2.39,.93,;3.72,.16,;1.06,.16,;1.06,-1.38,;2.39,-2.15,;2.39,-3.69,;3.72,-4.46,;4.12,-5.95,;5.61,-5.55,;5.21,-4.06,;6.94,-6.32,;6.94,-7.86,;8.28,-5.55,;9.61,-6.32,;-.28,.93,;-1.61,.16,;-6.94,-1.38,;-8.28,-2.15,)| Show InChI InChI=1S/C31H38Cl2N6O5/c1-5-25(40)38-17-21(18-38)44-12-11-39-29-20(16-35-31(36-29)34-15-19-7-9-37(6-2)10-8-19)13-22(30(39)41)26-27(32)23(42-3)14-24(43-4)28(26)33/h5,13-14,16,19,21H,1,6-12,15,17-18H2,2-4H3,(H,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287531
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)Show SMILES CCN1CCC(CNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-9.61,-6,;-9.61,-4.46,;-8.28,-3.69,;-6.94,-4.46,;-5.61,-3.69,;-5.61,-2.15,;-4.28,-1.38,;-4.28,.16,;-2.94,.93,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;2.39,2.47,;3.72,3.24,;3.72,4.78,;2.39,5.55,;5.06,5.55,;5.06,7.09,;6.39,7.86,;6.39,4.78,;6.39,3.24,;7.73,2.47,;9.06,3.24,;5.06,2.47,;5.06,.93,;2.39,.93,;3.72,.16,;1.06,.16,;1.06,-1.38,;2.39,-2.15,;2.39,-3.69,;3.72,-4.46,;4.12,-5.95,;5.61,-5.55,;5.21,-4.06,;6.94,-6.32,;6.94,-7.86,;8.28,-5.55,;9.61,-6.32,;-.28,.93,;-1.61,.16,;-6.94,-1.38,;-8.28,-2.15,)| Show InChI InChI=1S/C31H38Cl2N6O5/c1-5-25(40)38-17-21(18-38)44-12-11-39-29-20(16-35-31(36-29)34-15-19-7-9-37(6-2)10-8-19)13-22(30(39)41)26-27(32)23(42-3)14-24(43-4)28(26)33/h5,13-14,16,19,21H,1,6-12,15,17-18H2,2-4H3,(H,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287531
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)Show SMILES CCN1CCC(CNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-9.61,-6,;-9.61,-4.46,;-8.28,-3.69,;-6.94,-4.46,;-5.61,-3.69,;-5.61,-2.15,;-4.28,-1.38,;-4.28,.16,;-2.94,.93,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;2.39,2.47,;3.72,3.24,;3.72,4.78,;2.39,5.55,;5.06,5.55,;5.06,7.09,;6.39,7.86,;6.39,4.78,;6.39,3.24,;7.73,2.47,;9.06,3.24,;5.06,2.47,;5.06,.93,;2.39,.93,;3.72,.16,;1.06,.16,;1.06,-1.38,;2.39,-2.15,;2.39,-3.69,;3.72,-4.46,;4.12,-5.95,;5.61,-5.55,;5.21,-4.06,;6.94,-6.32,;6.94,-7.86,;8.28,-5.55,;9.61,-6.32,;-.28,.93,;-1.61,.16,;-6.94,-1.38,;-8.28,-2.15,)| Show InChI InChI=1S/C31H38Cl2N6O5/c1-5-25(40)38-17-21(18-38)44-12-11-39-29-20(16-35-31(36-29)34-15-19-7-9-37(6-2)10-8-19)13-22(30(39)41)26-27(32)23(42-3)14-24(43-4)28(26)33/h5,13-14,16,19,21H,1,6-12,15,17-18H2,2-4H3,(H,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |