Found 3 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287545' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287545
![PNG](/data/jpeg/tenK28/BindingDB_287545.png) (1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)cc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(5.06,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C30H35Cl2N5O6/c1-4-26(38)36-17-20(18-36)43-12-9-37-22-14-25(33-5-6-35-7-10-42-11-8-35)34-16-19(22)13-21(30(37)39)27-28(31)23(40-2)15-24(41-3)29(27)32/h4,13-16,20H,1,5-12,17-18H2,2-3H3,(H,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287545
![PNG](/data/jpeg/tenK28/BindingDB_287545.png) (1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)cc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(5.06,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C30H35Cl2N5O6/c1-4-26(38)36-17-20(18-36)43-12-9-37-22-14-25(33-5-6-35-7-10-42-11-8-35)34-16-19(22)13-21(30(37)39)27-28(31)23(40-2)15-24(41-3)29(27)32/h4,13-16,20H,1,5-12,17-18H2,2-3H3,(H,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287545
![PNG](/data/jpeg/tenK28/BindingDB_287545.png) (1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)cc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(5.06,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C30H35Cl2N5O6/c1-4-26(38)36-17-20(18-36)43-12-9-37-22-14-25(33-5-6-35-7-10-42-11-8-35)34-16-19(22)13-21(30(37)39)27-28(31)23(40-2)15-24(41-3)29(27)32/h4,13-16,20H,1,5-12,17-18H2,2-3H3,(H,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |