Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287559'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB850W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Principia Biopharma, Inc. Curated by ChEMBL					Assay Description Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...				J Med Chem 60: 6516-6527 (2017) Article DOI: 10.1021/acs.jmedchem.7b00360 BindingDB Entry DOI: 10.7270/Q2C53P3H
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Principia Biopharma, Inc. Curated by ChEMBL					Assay Description Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...				J Med Chem 60: 6516-6527 (2017) Article DOI: 10.1021/acs.jmedchem.7b00360 BindingDB Entry DOI: 10.7270/Q2C53P3H
					More data for this Ligand-Target Pair