Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM287560' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287560
![PNG](/data/jpeg/tenK28/BindingDB_287560.png) (1-(3-(4-acryloylpiperazin-1-yl)propyl)-3-(2,6-dich...)Show SMILES COCCOCCNc1cc2n(CCCN3CCN(CC3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-9.34,-8.09,;-9.34,-6.55,;-8,-5.78,;-8,-4.24,;-6.67,-3.47,;-6.67,-1.93,;-5.33,-1.16,;-5.33,.38,;-4,1.15,;-2.67,.38,;-1.33,1.15,;,.38,;,-1.16,;1.33,-1.93,;1.33,-3.47,;2.67,-4.24,;2.67,-5.78,;4,-6.55,;5.33,-5.78,;5.33,-4.24,;4,-3.46,;6.67,-6.55,;6.67,-8.09,;8,-5.78,;9.34,-6.55,;1.33,1.15,;2.67,.38,;1.33,2.69,;,3.46,;-1.33,2.69,;-2.67,3.46,;-4,2.69,;2.67,3.46,;2.67,5,;1.33,5.77,;4,5.78,;4,7.32,;5.33,8.09,;5.33,5,;5.33,3.46,;6.67,2.69,;8,3.46,;4,2.69,;4,1.15,)| Show InChI InChI=1S/C31H39Cl2N5O6/c1-5-27(39)37-12-10-36(11-13-37)8-6-9-38-23-18-26(34-7-14-44-16-15-41-2)35-20-21(23)17-22(31(38)40)28-29(32)24(42-3)19-25(43-4)30(28)33/h5,17-20H,1,6-16H2,2-4H3,(H,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287560
![PNG](/data/jpeg/tenK28/BindingDB_287560.png) (1-(3-(4-acryloylpiperazin-1-yl)propyl)-3-(2,6-dich...)Show SMILES COCCOCCNc1cc2n(CCCN3CCN(CC3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-9.34,-8.09,;-9.34,-6.55,;-8,-5.78,;-8,-4.24,;-6.67,-3.47,;-6.67,-1.93,;-5.33,-1.16,;-5.33,.38,;-4,1.15,;-2.67,.38,;-1.33,1.15,;,.38,;,-1.16,;1.33,-1.93,;1.33,-3.47,;2.67,-4.24,;2.67,-5.78,;4,-6.55,;5.33,-5.78,;5.33,-4.24,;4,-3.46,;6.67,-6.55,;6.67,-8.09,;8,-5.78,;9.34,-6.55,;1.33,1.15,;2.67,.38,;1.33,2.69,;,3.46,;-1.33,2.69,;-2.67,3.46,;-4,2.69,;2.67,3.46,;2.67,5,;1.33,5.77,;4,5.78,;4,7.32,;5.33,8.09,;5.33,5,;5.33,3.46,;6.67,2.69,;8,3.46,;4,2.69,;4,1.15,)| Show InChI InChI=1S/C31H39Cl2N5O6/c1-5-27(39)37-12-10-36(11-13-37)8-6-9-38-23-18-26(34-7-14-44-16-15-41-2)35-20-21(23)17-22(31(38)40)28-29(32)24(42-3)19-25(43-4)30(28)33/h5,17-20H,1,6-16H2,2-4H3,(H,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |