Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM102515' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102515
(US8536175, 43)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCOCC3)nc2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.77,2.67,;5.77,,;6.54,-1.33,;5.77,-2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.16,1.33,;-1.16,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.62,2.67,;-10.39,1.33,;-9.62,,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)| Show InChI InChI=1S/C27H25Cl2N5O4/c1-36-20-13-21(37-2)24(29)22(23(20)28)18-5-6-19(26-25(18)30-7-8-31-26)27(35)33-16-3-4-17(32-14-16)15-34-9-11-38-12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102515
(US8536175, 43)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCOCC3)nc2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.77,2.67,;5.77,,;6.54,-1.33,;5.77,-2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.16,1.33,;-1.16,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.62,2.67,;-10.39,1.33,;-9.62,,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)| Show InChI InChI=1S/C27H25Cl2N5O4/c1-36-20-13-21(37-2)24(29)22(23(20)28)18-5-6-19(26-25(18)30-7-8-31-26)27(35)33-16-3-4-17(32-14-16)15-34-9-11-38-12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Protein kinase activity measured by the microfluidic caliper method. |
US Patent US8536175 (2013)
BindingDB Entry DOI: 10.7270/Q27D2SSH |
More data for this
Ligand-Target Pair | |
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