Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM102532' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102532
(US8536175, 112)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNC(C)(C)C3)nc2)c2nccnc12 |(8.7,-13.78,;7.36,-14.55,;7.36,-16.09,;8.7,-16.86,;8.7,-18.4,;10.03,-19.17,;11.36,-18.4,;7.36,-19.17,;7.36,-20.71,;6.03,-18.4,;6.03,-16.86,;4.69,-16.09,;4.69,-19.17,;3.36,-18.4,;2.03,-19.17,;2.03,-20.71,;.69,-21.48,;.69,-23.02,;-.64,-20.71,;-1.97,-21.48,;-3.31,-20.71,;-4.64,-21.48,;-4.64,-23.02,;-5.98,-23.79,;-7.31,-23.02,;-7.31,-21.48,;-8.64,-20.71,;-9.98,-21.48,;-9.98,-23.02,;-11.31,-23.79,;-10.38,-24.51,;-8.64,-23.79,;-3.31,-23.79,;-1.97,-23.02,;3.36,-21.48,;3.36,-23.02,;4.69,-23.79,;6.03,-23.02,;6.03,-21.48,;4.69,-20.71,)| Show InChI InChI=1S/C29H30Cl2N6O3/c1-29(2)16-37(12-11-35-29)15-18-6-5-17(14-34-18)36-28(38)20-8-7-19(26-27(20)33-10-9-32-26)23-24(30)21(39-3)13-22(40-4)25(23)31/h5-10,13-14,35H,11-12,15-16H2,1-4H3,(H,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102532
(US8536175, 112)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNC(C)(C)C3)nc2)c2nccnc12 |(8.7,-13.78,;7.36,-14.55,;7.36,-16.09,;8.7,-16.86,;8.7,-18.4,;10.03,-19.17,;11.36,-18.4,;7.36,-19.17,;7.36,-20.71,;6.03,-18.4,;6.03,-16.86,;4.69,-16.09,;4.69,-19.17,;3.36,-18.4,;2.03,-19.17,;2.03,-20.71,;.69,-21.48,;.69,-23.02,;-.64,-20.71,;-1.97,-21.48,;-3.31,-20.71,;-4.64,-21.48,;-4.64,-23.02,;-5.98,-23.79,;-7.31,-23.02,;-7.31,-21.48,;-8.64,-20.71,;-9.98,-21.48,;-9.98,-23.02,;-11.31,-23.79,;-10.38,-24.51,;-8.64,-23.79,;-3.31,-23.79,;-1.97,-23.02,;3.36,-21.48,;3.36,-23.02,;4.69,-23.79,;6.03,-23.02,;6.03,-21.48,;4.69,-20.71,)| Show InChI InChI=1S/C29H30Cl2N6O3/c1-29(2)16-37(12-11-35-29)15-18-6-5-17(14-34-18)36-28(38)20-8-7-19(26-27(20)33-10-9-32-26)23-24(30)21(39-3)13-22(40-4)25(23)31/h5-10,13-14,35H,11-12,15-16H2,1-4H3,(H,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Protein kinase activity measured by the microfluidic caliper method. |
US Patent US8536175 (2013)
BindingDB Entry DOI: 10.7270/Q27D2SSH |
More data for this
Ligand-Target Pair | |
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