Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM102547' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102547
(US8536175, 173)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN(C)CCN(C)C)cn2)c2ncccc12 |(11.55,2.66,;10.01,2.66,;9.24,1.33,;10.01,-0,;9.24,-1.34,;10.01,-2.67,;11.55,-2.67,;7.7,-1.34,;6.93,-2.67,;6.93,-0,;7.7,1.33,;6.93,2.66,;5.39,-0,;4.62,1.33,;3.08,1.33,;2.31,-0,;.77,-0,;-0,1.33,;-0,-1.34,;-1.54,-1.34,;-2.31,-0,;-3.85,-0,;-4.62,-1.34,;-6.16,-1.34,;-6.93,-0,;-6.16,1.33,;-8.47,-0,;-9.24,-1.34,;-10.78,-1.34,;-11.55,-2.67,;-11.55,-0,;-3.85,-2.67,;-2.31,-2.67,;3.08,-1.34,;2.31,-2.67,;3.08,-4.01,;4.62,-4.01,;5.39,-2.67,;4.62,-1.34,)| Show InChI InChI=1S/C29H31Cl2N5O3/c1-35(2)13-14-36(3)17-18-8-11-24(33-16-18)34-29(37)21-10-9-19(20-7-6-12-32-28(20)21)25-26(30)22(38-4)15-23(39-5)27(25)31/h6-12,15-16H,13-14,17H2,1-5H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102547
(US8536175, 173)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN(C)CCN(C)C)cn2)c2ncccc12 |(11.55,2.66,;10.01,2.66,;9.24,1.33,;10.01,-0,;9.24,-1.34,;10.01,-2.67,;11.55,-2.67,;7.7,-1.34,;6.93,-2.67,;6.93,-0,;7.7,1.33,;6.93,2.66,;5.39,-0,;4.62,1.33,;3.08,1.33,;2.31,-0,;.77,-0,;-0,1.33,;-0,-1.34,;-1.54,-1.34,;-2.31,-0,;-3.85,-0,;-4.62,-1.34,;-6.16,-1.34,;-6.93,-0,;-6.16,1.33,;-8.47,-0,;-9.24,-1.34,;-10.78,-1.34,;-11.55,-2.67,;-11.55,-0,;-3.85,-2.67,;-2.31,-2.67,;3.08,-1.34,;2.31,-2.67,;3.08,-4.01,;4.62,-4.01,;5.39,-2.67,;4.62,-1.34,)| Show InChI InChI=1S/C29H31Cl2N5O3/c1-35(2)13-14-36(3)17-18-8-11-24(33-16-18)34-29(37)21-10-9-19(20-7-6-12-32-28(20)21)25-26(30)22(38-4)15-23(39-5)27(25)31/h6-12,15-16H,13-14,17H2,1-5H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Protein kinase activity measured by the microfluidic caliper method. |
US Patent US8536175 (2013)
BindingDB Entry DOI: 10.7270/Q27D2SSH |
More data for this
Ligand-Target Pair | |
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