Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50120389' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120389
(CHEMBL3616751)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C181H280N44O56/c1-18-100(10)148(174(274)201-103(13)153(253)209-128(82-109-85-193-114-50-40-39-49-112(109)114)164(264)211-124(78-97(4)5)165(265)221-146(98(6)7)172(272)208-116(53-44-72-192-180(186)187)156(256)194-87-136(235)202-115(52-43-71-191-179(184)185)155(255)197-90-145(249)250)223-166(266)126(79-106-45-33-31-34-46-106)212-161(261)121(64-69-143(245)246)207-160(260)117(51-41-42-70-189-139(238)94-281-76-75-280-74-73-190-134(233)66-61-122(177(277)278)204-135(234)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-140(239)240)205-152(252)102(12)199-151(251)101(11)200-159(259)120(60-65-133(183)232)203-137(236)88-195-157(257)118(62-67-141(241)242)206-162(262)123(77-96(2)3)210-163(263)125(81-108-56-58-111(231)59-57-108)213-169(269)130(91-226)216-171(271)132(93-228)217-173(273)147(99(8)9)222-168(268)129(84-144(247)248)214-170(270)131(92-227)218-176(276)150(105(15)230)224-167(267)127(80-107-47-35-32-36-48-107)215-175(275)149(104(14)229)220-138(237)89-196-158(258)119(63-68-142(243)244)219-178(279)181(16,17)225-154(254)113(182)83-110-86-188-95-198-110/h31-36,39-40,45-50,56-59,85-86,95-105,113,115-132,146-150,193,226-231H,18-30,37-38,41-44,51-55,60-84,87-94,182H2,1-17H3,(H2,183,232)(H,188,198)(H,189,238)(H,190,233)(H,194,256)(H,195,257)(H,196,258)(H,197,255)(H,199,251)(H,200,259)(H,201,274)(H,202,235)(H,203,236)(H,204,234)(H,205,252)(H,206,262)(H,207,260)(H,208,272)(H,209,253)(H,210,263)(H,211,264)(H,212,261)(H,213,269)(H,214,270)(H,215,275)(H,216,271)(H,217,273)(H,218,276)(H,219,279)(H,220,237)(H,221,265)(H,222,268)(H,223,266)(H,224,267)(H,225,254)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,277,278)(H4,184,185,191)(H4,186,187,192)/t100-,101-,102-,103-,104+,105+,113-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120389
(CHEMBL3616751)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C181H280N44O56/c1-18-100(10)148(174(274)201-103(13)153(253)209-128(82-109-85-193-114-50-40-39-49-112(109)114)164(264)211-124(78-97(4)5)165(265)221-146(98(6)7)172(272)208-116(53-44-72-192-180(186)187)156(256)194-87-136(235)202-115(52-43-71-191-179(184)185)155(255)197-90-145(249)250)223-166(266)126(79-106-45-33-31-34-46-106)212-161(261)121(64-69-143(245)246)207-160(260)117(51-41-42-70-189-139(238)94-281-76-75-280-74-73-190-134(233)66-61-122(177(277)278)204-135(234)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-140(239)240)205-152(252)102(12)199-151(251)101(11)200-159(259)120(60-65-133(183)232)203-137(236)88-195-157(257)118(62-67-141(241)242)206-162(262)123(77-96(2)3)210-163(263)125(81-108-56-58-111(231)59-57-108)213-169(269)130(91-226)216-171(271)132(93-228)217-173(273)147(99(8)9)222-168(268)129(84-144(247)248)214-170(270)131(92-227)218-176(276)150(105(15)230)224-167(267)127(80-107-47-35-32-36-48-107)215-175(275)149(104(14)229)220-138(237)89-196-158(258)119(63-68-142(243)244)219-178(279)181(16,17)225-154(254)113(182)83-110-86-188-95-198-110/h31-36,39-40,45-50,56-59,85-86,95-105,113,115-132,146-150,193,226-231H,18-30,37-38,41-44,51-55,60-84,87-94,182H2,1-17H3,(H2,183,232)(H,188,198)(H,189,238)(H,190,233)(H,194,256)(H,195,257)(H,196,258)(H,197,255)(H,199,251)(H,200,259)(H,201,274)(H,202,235)(H,203,236)(H,204,234)(H,205,252)(H,206,262)(H,207,260)(H,208,272)(H,209,253)(H,210,263)(H,211,264)(H,212,261)(H,213,269)(H,214,270)(H,215,275)(H,216,271)(H,217,273)(H,218,276)(H,219,279)(H,220,237)(H,221,265)(H,222,268)(H,223,266)(H,224,267)(H,225,254)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,277,278)(H4,184,185,191)(H4,186,187,192)/t100-,101-,102-,103-,104+,105+,113-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120389
(CHEMBL3616751)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C181H280N44O56/c1-18-100(10)148(174(274)201-103(13)153(253)209-128(82-109-85-193-114-50-40-39-49-112(109)114)164(264)211-124(78-97(4)5)165(265)221-146(98(6)7)172(272)208-116(53-44-72-192-180(186)187)156(256)194-87-136(235)202-115(52-43-71-191-179(184)185)155(255)197-90-145(249)250)223-166(266)126(79-106-45-33-31-34-46-106)212-161(261)121(64-69-143(245)246)207-160(260)117(51-41-42-70-189-139(238)94-281-76-75-280-74-73-190-134(233)66-61-122(177(277)278)204-135(234)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-140(239)240)205-152(252)102(12)199-151(251)101(11)200-159(259)120(60-65-133(183)232)203-137(236)88-195-157(257)118(62-67-141(241)242)206-162(262)123(77-96(2)3)210-163(263)125(81-108-56-58-111(231)59-57-108)213-169(269)130(91-226)216-171(271)132(93-228)217-173(273)147(99(8)9)222-168(268)129(84-144(247)248)214-170(270)131(92-227)218-176(276)150(105(15)230)224-167(267)127(80-107-47-35-32-36-48-107)215-175(275)149(104(14)229)220-138(237)89-196-158(258)119(63-68-142(243)244)219-178(279)181(16,17)225-154(254)113(182)83-110-86-188-95-198-110/h31-36,39-40,45-50,56-59,85-86,95-105,113,115-132,146-150,193,226-231H,18-30,37-38,41-44,51-55,60-84,87-94,182H2,1-17H3,(H2,183,232)(H,188,198)(H,189,238)(H,190,233)(H,194,256)(H,195,257)(H,196,258)(H,197,255)(H,199,251)(H,200,259)(H,201,274)(H,202,235)(H,203,236)(H,204,234)(H,205,252)(H,206,262)(H,207,260)(H,208,272)(H,209,253)(H,210,263)(H,211,264)(H,212,261)(H,213,269)(H,214,270)(H,215,275)(H,216,271)(H,217,273)(H,218,276)(H,219,279)(H,220,237)(H,221,265)(H,222,268)(H,223,266)(H,224,267)(H,225,254)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,277,278)(H4,184,185,191)(H4,186,187,192)/t100-,101-,102-,103-,104+,105+,113-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00500 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
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