Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50121397' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121397
(CHEMBL3616753)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C187H292N46O58/c1-18-105(10)154(180(282)209-108(13)159(261)217-133(86-114-89-201-119-50-40-39-49-117(114)119)170(272)219-129(82-102(4)5)171(273)229-152(103(6)7)178(280)216-121(53-44-72-200-186(193)194)162(264)203-92-142(244)210-120(52-43-71-199-185(191)192)161(263)202-91-139(190)241)231-172(274)131(83-111-45-33-31-34-46-111)220-167(269)126(64-69-150(255)256)215-166(268)122(51-41-42-70-196-145(247)98-290-79-78-289-76-74-198-146(248)99-291-80-77-288-75-73-197-140(242)66-61-127(183(285)286)212-141(243)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-147(249)250)213-158(260)107(12)207-157(259)106(11)208-165(267)125(60-65-138(189)240)211-143(245)93-204-163(265)123(62-67-148(251)252)214-168(270)128(81-101(2)3)218-169(271)130(85-113-56-58-116(239)59-57-113)221-175(277)135(95-234)224-177(279)137(97-236)225-179(281)153(104(8)9)230-174(276)134(88-151(257)258)222-176(278)136(96-235)226-182(284)156(110(15)238)232-173(275)132(84-112-47-35-32-36-48-112)223-181(283)155(109(14)237)228-144(246)94-205-164(266)124(63-68-149(253)254)227-184(287)187(16,17)233-160(262)118(188)87-115-90-195-100-206-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,201,234-239H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,240)(H2,190,241)(H,195,206)(H,196,247)(H,197,242)(H,198,248)(H,202,263)(H,203,264)(H,204,265)(H,205,266)(H,207,259)(H,208,267)(H,209,282)(H,210,244)(H,211,245)(H,212,243)(H,213,260)(H,214,270)(H,215,268)(H,216,280)(H,217,261)(H,218,271)(H,219,272)(H,220,269)(H,221,277)(H,222,278)(H,223,283)(H,224,279)(H,225,281)(H,226,284)(H,227,287)(H,228,246)(H,229,273)(H,230,276)(H,231,274)(H,232,275)(H,233,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,191,192,199)(H4,193,194,200)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121397
(CHEMBL3616753)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C187H292N46O58/c1-18-105(10)154(180(282)209-108(13)159(261)217-133(86-114-89-201-119-50-40-39-49-117(114)119)170(272)219-129(82-102(4)5)171(273)229-152(103(6)7)178(280)216-121(53-44-72-200-186(193)194)162(264)203-92-142(244)210-120(52-43-71-199-185(191)192)161(263)202-91-139(190)241)231-172(274)131(83-111-45-33-31-34-46-111)220-167(269)126(64-69-150(255)256)215-166(268)122(51-41-42-70-196-145(247)98-290-79-78-289-76-74-198-146(248)99-291-80-77-288-75-73-197-140(242)66-61-127(183(285)286)212-141(243)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-147(249)250)213-158(260)107(12)207-157(259)106(11)208-165(267)125(60-65-138(189)240)211-143(245)93-204-163(265)123(62-67-148(251)252)214-168(270)128(81-101(2)3)218-169(271)130(85-113-56-58-116(239)59-57-113)221-175(277)135(95-234)224-177(279)137(97-236)225-179(281)153(104(8)9)230-174(276)134(88-151(257)258)222-176(278)136(96-235)226-182(284)156(110(15)238)232-173(275)132(84-112-47-35-32-36-48-112)223-181(283)155(109(14)237)228-144(246)94-205-164(266)124(63-68-149(253)254)227-184(287)187(16,17)233-160(262)118(188)87-115-90-195-100-206-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,201,234-239H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,240)(H2,190,241)(H,195,206)(H,196,247)(H,197,242)(H,198,248)(H,202,263)(H,203,264)(H,204,265)(H,205,266)(H,207,259)(H,208,267)(H,209,282)(H,210,244)(H,211,245)(H,212,243)(H,213,260)(H,214,270)(H,215,268)(H,216,280)(H,217,261)(H,218,271)(H,219,272)(H,220,269)(H,221,277)(H,222,278)(H,223,283)(H,224,279)(H,225,281)(H,226,284)(H,227,287)(H,228,246)(H,229,273)(H,230,276)(H,231,274)(H,232,275)(H,233,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,191,192,199)(H4,193,194,200)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121397
(CHEMBL3616753)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C187H292N46O58/c1-18-105(10)154(180(282)209-108(13)159(261)217-133(86-114-89-201-119-50-40-39-49-117(114)119)170(272)219-129(82-102(4)5)171(273)229-152(103(6)7)178(280)216-121(53-44-72-200-186(193)194)162(264)203-92-142(244)210-120(52-43-71-199-185(191)192)161(263)202-91-139(190)241)231-172(274)131(83-111-45-33-31-34-46-111)220-167(269)126(64-69-150(255)256)215-166(268)122(51-41-42-70-196-145(247)98-290-79-78-289-76-74-198-146(248)99-291-80-77-288-75-73-197-140(242)66-61-127(183(285)286)212-141(243)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-147(249)250)213-158(260)107(12)207-157(259)106(11)208-165(267)125(60-65-138(189)240)211-143(245)93-204-163(265)123(62-67-148(251)252)214-168(270)128(81-101(2)3)218-169(271)130(85-113-56-58-116(239)59-57-113)221-175(277)135(95-234)224-177(279)137(97-236)225-179(281)153(104(8)9)230-174(276)134(88-151(257)258)222-176(278)136(96-235)226-182(284)156(110(15)238)232-173(275)132(84-112-47-35-32-36-48-112)223-181(283)155(109(14)237)228-144(246)94-205-164(266)124(63-68-149(253)254)227-184(287)187(16,17)233-160(262)118(188)87-115-90-195-100-206-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,201,234-239H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,240)(H2,190,241)(H,195,206)(H,196,247)(H,197,242)(H,198,248)(H,202,263)(H,203,264)(H,204,265)(H,205,266)(H,207,259)(H,208,267)(H,209,282)(H,210,244)(H,211,245)(H,212,243)(H,213,260)(H,214,270)(H,215,268)(H,216,280)(H,217,261)(H,218,271)(H,219,272)(H,220,269)(H,221,277)(H,222,278)(H,223,283)(H,224,279)(H,225,281)(H,226,284)(H,227,287)(H,228,246)(H,229,273)(H,230,276)(H,231,274)(H,232,275)(H,233,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,191,192,199)(H4,193,194,200)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00600 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
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