Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50121408' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121408
(CHEMBL3616758)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C190H294N46O60/c1-18-105(10)156(182(287)211-108(13)161(266)220-134(87-114-90-203-119-51-40-39-50-117(114)119)172(277)222-130(83-102(4)5)173(278)232-154(103(6)7)180(285)219-121(54-44-77-202-189(195)196)164(269)204-92-144(248)212-120(53-43-76-201-188(193)194)163(268)207-95-153(262)263)234-174(279)132(84-111-46-33-31-34-47-111)223-169(274)126(67-73-151(258)259)218-168(273)122(52-41-42-74-199-147(251)99-296-81-80-295-79-78-200-141(245)69-63-127(185(290)291)215-143(247)70-64-128(186(292)293)214-142(246)56-45-75-198-140(244)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-148(252)253)216-160(265)107(12)209-159(264)106(11)210-167(272)125(62-68-139(192)243)213-145(249)93-205-165(270)123(65-71-149(254)255)217-170(275)129(82-101(2)3)221-171(276)131(86-113-58-60-116(242)61-59-113)224-177(282)136(96-237)227-179(284)138(98-239)228-181(286)155(104(8)9)233-176(281)135(89-152(260)261)225-178(283)137(97-238)229-184(289)158(110(15)241)235-175(280)133(85-112-48-35-32-36-49-112)226-183(288)157(109(14)240)231-146(250)94-206-166(271)124(66-72-150(256)257)230-187(294)190(16,17)236-162(267)118(191)88-115-91-197-100-208-115/h31-36,39-40,46-51,58-61,90-91,100-110,118,120-138,154-158,203,237-242H,18-30,37-38,41-45,52-57,62-89,92-99,191H2,1-17H3,(H2,192,243)(H,197,208)(H,198,244)(H,199,251)(H,200,245)(H,204,269)(H,205,270)(H,206,271)(H,207,268)(H,209,264)(H,210,272)(H,211,287)(H,212,248)(H,213,249)(H,214,246)(H,215,247)(H,216,265)(H,217,275)(H,218,273)(H,219,285)(H,220,266)(H,221,276)(H,222,277)(H,223,274)(H,224,282)(H,225,283)(H,226,288)(H,227,284)(H,228,286)(H,229,289)(H,230,294)(H,231,250)(H,232,278)(H,233,281)(H,234,279)(H,235,280)(H,236,267)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,290,291)(H,292,293)(H4,193,194,201)(H4,195,196,202)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121408
(CHEMBL3616758)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C190H294N46O60/c1-18-105(10)156(182(287)211-108(13)161(266)220-134(87-114-90-203-119-51-40-39-50-117(114)119)172(277)222-130(83-102(4)5)173(278)232-154(103(6)7)180(285)219-121(54-44-77-202-189(195)196)164(269)204-92-144(248)212-120(53-43-76-201-188(193)194)163(268)207-95-153(262)263)234-174(279)132(84-111-46-33-31-34-47-111)223-169(274)126(67-73-151(258)259)218-168(273)122(52-41-42-74-199-147(251)99-296-81-80-295-79-78-200-141(245)69-63-127(185(290)291)215-143(247)70-64-128(186(292)293)214-142(246)56-45-75-198-140(244)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-148(252)253)216-160(265)107(12)209-159(264)106(11)210-167(272)125(62-68-139(192)243)213-145(249)93-205-165(270)123(65-71-149(254)255)217-170(275)129(82-101(2)3)221-171(276)131(86-113-58-60-116(242)61-59-113)224-177(282)136(96-237)227-179(284)138(98-239)228-181(286)155(104(8)9)233-176(281)135(89-152(260)261)225-178(283)137(97-238)229-184(289)158(110(15)241)235-175(280)133(85-112-48-35-32-36-49-112)226-183(288)157(109(14)240)231-146(250)94-206-166(271)124(66-72-150(256)257)230-187(294)190(16,17)236-162(267)118(191)88-115-91-197-100-208-115/h31-36,39-40,46-51,58-61,90-91,100-110,118,120-138,154-158,203,237-242H,18-30,37-38,41-45,52-57,62-89,92-99,191H2,1-17H3,(H2,192,243)(H,197,208)(H,198,244)(H,199,251)(H,200,245)(H,204,269)(H,205,270)(H,206,271)(H,207,268)(H,209,264)(H,210,272)(H,211,287)(H,212,248)(H,213,249)(H,214,246)(H,215,247)(H,216,265)(H,217,275)(H,218,273)(H,219,285)(H,220,266)(H,221,276)(H,222,277)(H,223,274)(H,224,282)(H,225,283)(H,226,288)(H,227,284)(H,228,286)(H,229,289)(H,230,294)(H,231,250)(H,232,278)(H,233,281)(H,234,279)(H,235,280)(H,236,267)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,290,291)(H,292,293)(H4,193,194,201)(H4,195,196,202)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121408
(CHEMBL3616758)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C190H294N46O60/c1-18-105(10)156(182(287)211-108(13)161(266)220-134(87-114-90-203-119-51-40-39-50-117(114)119)172(277)222-130(83-102(4)5)173(278)232-154(103(6)7)180(285)219-121(54-44-77-202-189(195)196)164(269)204-92-144(248)212-120(53-43-76-201-188(193)194)163(268)207-95-153(262)263)234-174(279)132(84-111-46-33-31-34-47-111)223-169(274)126(67-73-151(258)259)218-168(273)122(52-41-42-74-199-147(251)99-296-81-80-295-79-78-200-141(245)69-63-127(185(290)291)215-143(247)70-64-128(186(292)293)214-142(246)56-45-75-198-140(244)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-148(252)253)216-160(265)107(12)209-159(264)106(11)210-167(272)125(62-68-139(192)243)213-145(249)93-205-165(270)123(65-71-149(254)255)217-170(275)129(82-101(2)3)221-171(276)131(86-113-58-60-116(242)61-59-113)224-177(282)136(96-237)227-179(284)138(98-239)228-181(286)155(104(8)9)233-176(281)135(89-152(260)261)225-178(283)137(97-238)229-184(289)158(110(15)241)235-175(280)133(85-112-48-35-32-36-49-112)226-183(288)157(109(14)240)231-146(250)94-206-166(271)124(66-72-150(256)257)230-187(294)190(16,17)236-162(267)118(191)88-115-91-197-100-208-115/h31-36,39-40,46-51,58-61,90-91,100-110,118,120-138,154-158,203,237-242H,18-30,37-38,41-45,52-57,62-89,92-99,191H2,1-17H3,(H2,192,243)(H,197,208)(H,198,244)(H,199,251)(H,200,245)(H,204,269)(H,205,270)(H,206,271)(H,207,268)(H,209,264)(H,210,272)(H,211,287)(H,212,248)(H,213,249)(H,214,246)(H,215,247)(H,216,265)(H,217,275)(H,218,273)(H,219,285)(H,220,266)(H,221,276)(H,222,277)(H,223,274)(H,224,282)(H,225,283)(H,226,288)(H,227,284)(H,228,286)(H,229,289)(H,230,294)(H,231,250)(H,232,278)(H,233,281)(H,234,279)(H,235,280)(H,236,267)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,290,291)(H,292,293)(H4,193,194,201)(H4,195,196,202)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |