Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50121433' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121433
(CHEMBL3616759)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H291N45O57/c1-18-106(10)154(180(281)208-109(13)159(260)215-133(87-115-90-200-120-51-40-39-50-118(115)120)170(271)217-129(83-103(4)5)171(272)227-152(104(6)7)178(279)214-122(54-44-73-199-185(191)192)162(263)201-92-141(241)209-121(53-43-72-198-184(189)190)161(262)204-95-151(256)257)229-172(273)131(84-112-46-33-31-34-47-112)218-167(268)127(65-69-149(252)253)213-166(267)123(52-41-42-70-195-144(244)99-287-80-79-286-77-75-197-145(245)100-288-81-78-285-76-74-196-140(240)56-45-71-194-139(239)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-146(246)247)211-158(259)108(12)206-157(258)107(11)207-165(266)126(62-66-138(188)238)210-142(242)93-202-163(264)124(63-67-147(248)249)212-168(269)128(82-102(2)3)216-169(270)130(86-114-58-60-117(237)61-59-114)219-175(276)135(96-232)222-177(278)137(98-234)223-179(280)153(105(8)9)228-174(275)134(89-150(254)255)220-176(277)136(97-233)224-182(283)156(111(15)236)230-173(274)132(85-113-48-35-32-36-49-113)221-181(282)155(110(14)235)226-143(243)94-203-164(265)125(64-68-148(250)251)225-183(284)186(16,17)231-160(261)119(187)88-116-91-193-101-205-116/h31-36,39-40,46-51,58-61,90-91,101-111,119,121-137,152-156,200,232-237H,18-30,37-38,41-45,52-57,62-89,92-100,187H2,1-17H3,(H2,188,238)(H,193,205)(H,194,239)(H,195,244)(H,196,240)(H,197,245)(H,201,263)(H,202,264)(H,203,265)(H,204,262)(H,206,258)(H,207,266)(H,208,281)(H,209,241)(H,210,242)(H,211,259)(H,212,269)(H,213,267)(H,214,279)(H,215,260)(H,216,270)(H,217,271)(H,218,268)(H,219,276)(H,220,277)(H,221,282)(H,222,278)(H,223,280)(H,224,283)(H,225,284)(H,226,243)(H,227,272)(H,228,275)(H,229,273)(H,230,274)(H,231,261)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,189,190,198)(H4,191,192,199)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121433
(CHEMBL3616759)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H291N45O57/c1-18-106(10)154(180(281)208-109(13)159(260)215-133(87-115-90-200-120-51-40-39-50-118(115)120)170(271)217-129(83-103(4)5)171(272)227-152(104(6)7)178(279)214-122(54-44-73-199-185(191)192)162(263)201-92-141(241)209-121(53-43-72-198-184(189)190)161(262)204-95-151(256)257)229-172(273)131(84-112-46-33-31-34-47-112)218-167(268)127(65-69-149(252)253)213-166(267)123(52-41-42-70-195-144(244)99-287-80-79-286-77-75-197-145(245)100-288-81-78-285-76-74-196-140(240)56-45-71-194-139(239)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-146(246)247)211-158(259)108(12)206-157(258)107(11)207-165(266)126(62-66-138(188)238)210-142(242)93-202-163(264)124(63-67-147(248)249)212-168(269)128(82-102(2)3)216-169(270)130(86-114-58-60-117(237)61-59-114)219-175(276)135(96-232)222-177(278)137(98-234)223-179(280)153(105(8)9)228-174(275)134(89-150(254)255)220-176(277)136(97-233)224-182(283)156(111(15)236)230-173(274)132(85-113-48-35-32-36-49-113)221-181(282)155(110(14)235)226-143(243)94-203-164(265)125(64-68-148(250)251)225-183(284)186(16,17)231-160(261)119(187)88-116-91-193-101-205-116/h31-36,39-40,46-51,58-61,90-91,101-111,119,121-137,152-156,200,232-237H,18-30,37-38,41-45,52-57,62-89,92-100,187H2,1-17H3,(H2,188,238)(H,193,205)(H,194,239)(H,195,244)(H,196,240)(H,197,245)(H,201,263)(H,202,264)(H,203,265)(H,204,262)(H,206,258)(H,207,266)(H,208,281)(H,209,241)(H,210,242)(H,211,259)(H,212,269)(H,213,267)(H,214,279)(H,215,260)(H,216,270)(H,217,271)(H,218,268)(H,219,276)(H,220,277)(H,221,282)(H,222,278)(H,223,280)(H,224,283)(H,225,284)(H,226,243)(H,227,272)(H,228,275)(H,229,273)(H,230,274)(H,231,261)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,189,190,198)(H4,191,192,199)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121433
(CHEMBL3616759)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H291N45O57/c1-18-106(10)154(180(281)208-109(13)159(260)215-133(87-115-90-200-120-51-40-39-50-118(115)120)170(271)217-129(83-103(4)5)171(272)227-152(104(6)7)178(279)214-122(54-44-73-199-185(191)192)162(263)201-92-141(241)209-121(53-43-72-198-184(189)190)161(262)204-95-151(256)257)229-172(273)131(84-112-46-33-31-34-47-112)218-167(268)127(65-69-149(252)253)213-166(267)123(52-41-42-70-195-144(244)99-287-80-79-286-77-75-197-145(245)100-288-81-78-285-76-74-196-140(240)56-45-71-194-139(239)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-146(246)247)211-158(259)108(12)206-157(258)107(11)207-165(266)126(62-66-138(188)238)210-142(242)93-202-163(264)124(63-67-147(248)249)212-168(269)128(82-102(2)3)216-169(270)130(86-114-58-60-117(237)61-59-114)219-175(276)135(96-232)222-177(278)137(98-234)223-179(280)153(105(8)9)228-174(275)134(89-150(254)255)220-176(277)136(97-233)224-182(283)156(111(15)236)230-173(274)132(85-113-48-35-32-36-49-113)221-181(282)155(110(14)235)226-143(243)94-203-164(265)125(64-68-148(250)251)225-183(284)186(16,17)231-160(261)119(187)88-116-91-193-101-205-116/h31-36,39-40,46-51,58-61,90-91,101-111,119,121-137,152-156,200,232-237H,18-30,37-38,41-45,52-57,62-89,92-100,187H2,1-17H3,(H2,188,238)(H,193,205)(H,194,239)(H,195,244)(H,196,240)(H,197,245)(H,201,263)(H,202,264)(H,203,265)(H,204,262)(H,206,258)(H,207,266)(H,208,281)(H,209,241)(H,210,242)(H,211,259)(H,212,269)(H,213,267)(H,214,279)(H,215,260)(H,216,270)(H,217,271)(H,218,268)(H,219,276)(H,220,277)(H,221,282)(H,222,278)(H,223,280)(H,224,283)(H,225,284)(H,226,243)(H,227,272)(H,228,275)(H,229,273)(H,230,274)(H,231,261)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,189,190,198)(H4,191,192,199)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0210 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
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