Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50121460' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121460
(CHEMBL3616754)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C193H302N46O62/c1-18-110(10)160(186(290)215-113(13)165(269)223-138(90-119-93-207-124-50-40-39-49-122(119)124)176(280)225-134(86-107(4)5)177(281)235-158(108(6)7)184(288)222-126(53-44-72-206-192(198)199)168(272)208-95-146(249)216-125(52-43-71-205-191(196)197)167(271)211-98-157(265)266)237-178(282)136(87-116-45-33-31-34-46-116)226-173(277)131(64-69-155(261)262)221-172(276)127(51-41-42-70-201-149(252)102-299-82-80-297-77-74-203-151(254)104-301-84-81-298-78-75-204-150(253)103-300-83-79-296-76-73-202-144(247)66-61-132(189(293)294)218-145(248)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-152(255)256)219-164(268)112(12)213-163(267)111(11)214-171(275)130(60-65-143(195)246)217-147(250)96-209-169(273)128(62-67-153(257)258)220-174(278)133(85-106(2)3)224-175(279)135(89-118-56-58-121(245)59-57-118)227-181(285)140(99-240)230-183(287)142(101-242)231-185(289)159(109(8)9)236-180(284)139(92-156(263)264)228-182(286)141(100-241)232-188(292)162(115(15)244)238-179(283)137(88-117-47-35-32-36-48-117)229-187(291)161(114(14)243)234-148(251)97-210-170(274)129(63-68-154(259)260)233-190(295)193(16,17)239-166(270)123(194)91-120-94-200-105-212-120/h31-36,39-40,45-50,56-59,93-94,105-115,123,125-142,158-162,207,240-245H,18-30,37-38,41-44,51-55,60-92,95-104,194H2,1-17H3,(H2,195,246)(H,200,212)(H,201,252)(H,202,247)(H,203,254)(H,204,253)(H,208,272)(H,209,273)(H,210,274)(H,211,271)(H,213,267)(H,214,275)(H,215,290)(H,216,249)(H,217,250)(H,218,248)(H,219,268)(H,220,278)(H,221,276)(H,222,288)(H,223,269)(H,224,279)(H,225,280)(H,226,277)(H,227,285)(H,228,286)(H,229,291)(H,230,287)(H,231,289)(H,232,292)(H,233,295)(H,234,251)(H,235,281)(H,236,284)(H,237,282)(H,238,283)(H,239,270)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,293,294)(H4,196,197,205)(H4,198,199,206)/t110-,111-,112-,113-,114+,115+,123-,125-,126-,127-,128-,129-,130-,131-,132+,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,158-,159-,160-,161-,162-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121460
(CHEMBL3616754)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C193H302N46O62/c1-18-110(10)160(186(290)215-113(13)165(269)223-138(90-119-93-207-124-50-40-39-49-122(119)124)176(280)225-134(86-107(4)5)177(281)235-158(108(6)7)184(288)222-126(53-44-72-206-192(198)199)168(272)208-95-146(249)216-125(52-43-71-205-191(196)197)167(271)211-98-157(265)266)237-178(282)136(87-116-45-33-31-34-46-116)226-173(277)131(64-69-155(261)262)221-172(276)127(51-41-42-70-201-149(252)102-299-82-80-297-77-74-203-151(254)104-301-84-81-298-78-75-204-150(253)103-300-83-79-296-76-73-202-144(247)66-61-132(189(293)294)218-145(248)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-152(255)256)219-164(268)112(12)213-163(267)111(11)214-171(275)130(60-65-143(195)246)217-147(250)96-209-169(273)128(62-67-153(257)258)220-174(278)133(85-106(2)3)224-175(279)135(89-118-56-58-121(245)59-57-118)227-181(285)140(99-240)230-183(287)142(101-242)231-185(289)159(109(8)9)236-180(284)139(92-156(263)264)228-182(286)141(100-241)232-188(292)162(115(15)244)238-179(283)137(88-117-47-35-32-36-48-117)229-187(291)161(114(14)243)234-148(251)97-210-170(274)129(63-68-154(259)260)233-190(295)193(16,17)239-166(270)123(194)91-120-94-200-105-212-120/h31-36,39-40,45-50,56-59,93-94,105-115,123,125-142,158-162,207,240-245H,18-30,37-38,41-44,51-55,60-92,95-104,194H2,1-17H3,(H2,195,246)(H,200,212)(H,201,252)(H,202,247)(H,203,254)(H,204,253)(H,208,272)(H,209,273)(H,210,274)(H,211,271)(H,213,267)(H,214,275)(H,215,290)(H,216,249)(H,217,250)(H,218,248)(H,219,268)(H,220,278)(H,221,276)(H,222,288)(H,223,269)(H,224,279)(H,225,280)(H,226,277)(H,227,285)(H,228,286)(H,229,291)(H,230,287)(H,231,289)(H,232,292)(H,233,295)(H,234,251)(H,235,281)(H,236,284)(H,237,282)(H,238,283)(H,239,270)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,293,294)(H4,196,197,205)(H4,198,199,206)/t110-,111-,112-,113-,114+,115+,123-,125-,126-,127-,128-,129-,130-,131-,132+,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,158-,159-,160-,161-,162-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121460
(CHEMBL3616754)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C193H302N46O62/c1-18-110(10)160(186(290)215-113(13)165(269)223-138(90-119-93-207-124-50-40-39-49-122(119)124)176(280)225-134(86-107(4)5)177(281)235-158(108(6)7)184(288)222-126(53-44-72-206-192(198)199)168(272)208-95-146(249)216-125(52-43-71-205-191(196)197)167(271)211-98-157(265)266)237-178(282)136(87-116-45-33-31-34-46-116)226-173(277)131(64-69-155(261)262)221-172(276)127(51-41-42-70-201-149(252)102-299-82-80-297-77-74-203-151(254)104-301-84-81-298-78-75-204-150(253)103-300-83-79-296-76-73-202-144(247)66-61-132(189(293)294)218-145(248)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-152(255)256)219-164(268)112(12)213-163(267)111(11)214-171(275)130(60-65-143(195)246)217-147(250)96-209-169(273)128(62-67-153(257)258)220-174(278)133(85-106(2)3)224-175(279)135(89-118-56-58-121(245)59-57-118)227-181(285)140(99-240)230-183(287)142(101-242)231-185(289)159(109(8)9)236-180(284)139(92-156(263)264)228-182(286)141(100-241)232-188(292)162(115(15)244)238-179(283)137(88-117-47-35-32-36-48-117)229-187(291)161(114(14)243)234-148(251)97-210-170(274)129(63-68-154(259)260)233-190(295)193(16,17)239-166(270)123(194)91-120-94-200-105-212-120/h31-36,39-40,45-50,56-59,93-94,105-115,123,125-142,158-162,207,240-245H,18-30,37-38,41-44,51-55,60-92,95-104,194H2,1-17H3,(H2,195,246)(H,200,212)(H,201,252)(H,202,247)(H,203,254)(H,204,253)(H,208,272)(H,209,273)(H,210,274)(H,211,271)(H,213,267)(H,214,275)(H,215,290)(H,216,249)(H,217,250)(H,218,248)(H,219,268)(H,220,278)(H,221,276)(H,222,288)(H,223,269)(H,224,279)(H,225,280)(H,226,277)(H,227,285)(H,228,286)(H,229,291)(H,230,287)(H,231,289)(H,232,292)(H,233,295)(H,234,251)(H,235,281)(H,236,284)(H,237,282)(H,238,283)(H,239,270)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,293,294)(H4,196,197,205)(H4,198,199,206)/t110-,111-,112-,113-,114+,115+,123-,125-,126-,127-,128-,129-,130-,131-,132+,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,158-,159-,160-,161-,162-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |