Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50275565' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon-like peptide 1 receptor
(Macaca fascicularis) | BDBM50275565
(CHEMBL4125912)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C173H267N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-38-54-130(225)196-117(171(266)267)60-65-129(224)181-69-42-41-51-112(154(249)200-116(63-68-136(233)234)155(250)205-121(74-101-45-34-32-35-46-101)160(255)215-141(94(11)19-2)168(263)193-98(15)147(242)202-123(77-104-80-184-109-50-40-39-49-107(104)109)158(253)204-119(73-91(5)6)159(254)213-139(92(7)8)166(261)201-111(53-44-71-183-173(178)179)150(245)185-82-131(226)194-110(52-43-70-182-172(176)177)149(244)188-85-138(237)238)197-145(240)96(13)190-144(239)95(12)192-153(248)115(59-64-128(175)223)195-132(227)83-186-152(247)114(62-67-135(231)232)199-156(251)118(72-90(3)4)203-157(252)120(76-103-55-57-106(222)58-56-103)206-163(258)125(86-217)209-165(260)127(88-219)210-167(262)140(93(9)10)214-162(257)124(79-137(235)236)207-164(259)126(87-218)211-170(265)143(100(17)221)216-161(256)122(75-102-47-36-33-37-48-102)208-169(264)142(99(16)220)212-133(228)84-187-151(246)113(61-66-134(229)230)198-146(241)97(14)191-148(243)108(174)78-105-81-180-89-189-105/h32-37,39-40,45-50,55-58,80-81,89-100,108,110-127,139-143,184,217-222H,18-31,38,41-44,51-54,59-79,82-88,174H2,1-17H3,(H2,175,223)(H,180,189)(H,181,224)(H,185,245)(H,186,247)(H,187,246)(H,188,244)(H,190,239)(H,191,243)(H,192,248)(H,193,263)(H,194,226)(H,195,227)(H,196,225)(H,197,240)(H,198,241)(H,199,251)(H,200,249)(H,201,261)(H,202,242)(H,203,252)(H,204,253)(H,205,250)(H,206,258)(H,207,259)(H,208,264)(H,209,260)(H,210,262)(H,211,265)(H,212,228)(H,213,254)(H,214,257)(H,215,255)(H,216,256)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,266,267)(H4,176,177,182)(H4,178,179,183)/t94-,95-,96-,97-,98-,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,139-,140-,141-,142-,143-/m0/s1 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.00410 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description Agonist activity at monkey GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292 BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50275565
(CHEMBL4125912)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C173H267N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-38-54-130(225)196-117(171(266)267)60-65-129(224)181-69-42-41-51-112(154(249)200-116(63-68-136(233)234)155(250)205-121(74-101-45-34-32-35-46-101)160(255)215-141(94(11)19-2)168(263)193-98(15)147(242)202-123(77-104-80-184-109-50-40-39-49-107(104)109)158(253)204-119(73-91(5)6)159(254)213-139(92(7)8)166(261)201-111(53-44-71-183-173(178)179)150(245)185-82-131(226)194-110(52-43-70-182-172(176)177)149(244)188-85-138(237)238)197-145(240)96(13)190-144(239)95(12)192-153(248)115(59-64-128(175)223)195-132(227)83-186-152(247)114(62-67-135(231)232)199-156(251)118(72-90(3)4)203-157(252)120(76-103-55-57-106(222)58-56-103)206-163(258)125(86-217)209-165(260)127(88-219)210-167(262)140(93(9)10)214-162(257)124(79-137(235)236)207-164(259)126(87-218)211-170(265)143(100(17)221)216-161(256)122(75-102-47-36-33-37-48-102)208-169(264)142(99(16)220)212-133(228)84-187-151(246)113(61-66-134(229)230)198-146(241)97(14)191-148(243)108(174)78-105-81-180-89-189-105/h32-37,39-40,45-50,55-58,80-81,89-100,108,110-127,139-143,184,217-222H,18-31,38,41-44,51-54,59-79,82-88,174H2,1-17H3,(H2,175,223)(H,180,189)(H,181,224)(H,185,245)(H,186,247)(H,187,246)(H,188,244)(H,190,239)(H,191,243)(H,192,248)(H,193,263)(H,194,226)(H,195,227)(H,196,225)(H,197,240)(H,198,241)(H,199,251)(H,200,249)(H,201,261)(H,202,242)(H,203,252)(H,204,253)(H,205,250)(H,206,258)(H,207,259)(H,208,264)(H,209,260)(H,210,262)(H,211,265)(H,212,228)(H,213,254)(H,214,257)(H,215,255)(H,216,256)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,266,267)(H4,176,177,182)(H4,178,179,183)/t94-,95-,96-,97-,98-,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,139-,140-,141-,142-,143-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.00640 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description Agonist activity at human GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292 BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this Ligand-Target Pair | |