Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50393564' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393564
![PNG](/data/jpeg/tenK5039/BindingDB_50393564.png) (CHEMBL2158392)Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccccc2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1ccccc1)C(O)=O)C(O)=O |r,wU:18.19,25.27,43.47,17.17,wD:25.54,17.57,(30.33,-18.46,;31.67,-17.7,;33,-18.48,;31.68,-19.24,;31.68,-16.16,;33.02,-15.4,;34.35,-16.18,;33.03,-13.86,;31.7,-13.08,;30.36,-13.84,;29.03,-13.06,;29.05,-11.52,;30.38,-10.76,;31.71,-11.53,;27.73,-10.74,;26.39,-11.5,;27.74,-9.2,;26.67,-8.09,;26.67,-6.55,;27.99,-5.76,;29.33,-6.51,;30.65,-5.72,;30.62,-4.17,;29.27,-3.43,;27.95,-4.22,;25.13,-6.55,;24.36,-5.22,;25.13,-3.88,;26.67,-3.88,;24.36,-2.55,;25.13,-1.22,;24.36,.11,;22.82,.11,;22.05,1.44,;22.81,2.78,;22.04,4.11,;24.35,2.78,;25.12,4.12,;26.66,4.12,;24.35,5.45,;25.88,5.46,;22.05,-1.23,;22.82,-2.56,;25.13,-8.09,;24.34,-9.39,;22.79,-9.36,;21.99,-10.67,;22.72,-12.02,;24.27,-12.06,;25.06,-10.73,;23.58,-6.55,;22.81,-5.22,;22.81,-7.89,;28.2,-8.09,;28.97,-9.42,;28.72,-7.03,)| Show InChI InChI=1S/C42H44N4O10/c1-39(2,3)55-37(53)43-29-21-17-27(18-22-29)33(47)45-41(35(49)50)31(25-13-9-7-10-14-25)42(36(51)52,32(41)26-15-11-8-12-16-26)46-34(48)28-19-23-30(24-20-28)44-38(54)56-40(4,5)6/h7-24,31-32H,1-6H3,(H,43,53)(H,44,54)(H,45,47)(H,46,48)(H,49,50)(H,51,52)/t31-,32+,41+,42- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cells |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393564
![PNG](/data/jpeg/tenK5039/BindingDB_50393564.png) (CHEMBL2158392)Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccccc2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1ccccc1)C(O)=O)C(O)=O |r,wU:18.19,25.27,43.47,17.17,wD:25.54,17.57,(30.33,-18.46,;31.67,-17.7,;33,-18.48,;31.68,-19.24,;31.68,-16.16,;33.02,-15.4,;34.35,-16.18,;33.03,-13.86,;31.7,-13.08,;30.36,-13.84,;29.03,-13.06,;29.05,-11.52,;30.38,-10.76,;31.71,-11.53,;27.73,-10.74,;26.39,-11.5,;27.74,-9.2,;26.67,-8.09,;26.67,-6.55,;27.99,-5.76,;29.33,-6.51,;30.65,-5.72,;30.62,-4.17,;29.27,-3.43,;27.95,-4.22,;25.13,-6.55,;24.36,-5.22,;25.13,-3.88,;26.67,-3.88,;24.36,-2.55,;25.13,-1.22,;24.36,.11,;22.82,.11,;22.05,1.44,;22.81,2.78,;22.04,4.11,;24.35,2.78,;25.12,4.12,;26.66,4.12,;24.35,5.45,;25.88,5.46,;22.05,-1.23,;22.82,-2.56,;25.13,-8.09,;24.34,-9.39,;22.79,-9.36,;21.99,-10.67,;22.72,-12.02,;24.27,-12.06,;25.06,-10.73,;23.58,-6.55,;22.81,-5.22,;22.81,-7.89,;28.2,-8.09,;28.97,-9.42,;28.72,-7.03,)| Show InChI InChI=1S/C42H44N4O10/c1-39(2,3)55-37(53)43-29-21-17-27(18-22-29)33(47)45-41(35(49)50)31(25-13-9-7-10-14-25)42(36(51)52,32(41)26-15-11-8-12-16-26)46-34(48)28-19-23-30(24-20-28)44-38(54)56-40(4,5)6/h7-24,31-32H,1-6H3,(H,43,53)(H,44,54)(H,45,47)(H,46,48)(H,49,50)(H,51,52)/t31-,32+,41+,42- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this Ligand-Target Pair | |