Found 6 hits Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50423189' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 933 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexametha... |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423189
(CHEMBL392319)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(C)CCCc2ccccc12)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-18-21(15-31-32(18)20-11-4-3-5-12-20)23(33)30-17-25(34,26(27,28)29)16-24(2)14-8-10-19-9-6-7-13-22(19)24/h3-7,9,11-13,15,34H,8,10,14,16-17H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 933 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexametha... |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
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