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Found 1 hit Enz. Inhib. hit(s) with Target = 'Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit' and Ligand = 'BDBM50509855'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM50509855
PNG
(CHEMBL4545322)
Show SMILES CC(=O)Nc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H22FN5O2/c1-16(31)27-20-8-4-18(5-9-20)22-21(17-2-6-19(25)7-3-17)28-24-23(26-10-11-30(22)24)29-12-14-32-15-13-29/h2-11H,12-15H2,1H3,(H,27,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a<1.00E+4n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair