Found 2 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2B' and Ligand = 'BDBM50505135' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor ionotropic, NMDA 2B
(Mus musculus) | BDBM50505135
(CHEMBL4453597)Show SMILES O[C@@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wU:15.17,1.1,(40.37,-25.74,;40.37,-27.28,;39.04,-26.5,;37.71,-27.27,;36.3,-26.63,;35.27,-27.77,;36.03,-29.11,;37.54,-28.8,;33.73,-27.77,;32.81,-26.51,;31.35,-26.98,;31.34,-28.53,;32.81,-29.01,;40.37,-28.82,;41.7,-29.6,;43.03,-28.84,;44.36,-29.61,;45.7,-28.84,;45.7,-27.29,;47.03,-26.52,;48.36,-27.29,;48.37,-28.84,;47.03,-29.61,;49.69,-26.51,;51.03,-27.28,;49.69,-24.97,;51.02,-25.73,;43.04,-27.29,;41.71,-26.52,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi & Co., Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced... |
Bioorg Med Chem Lett 29: 1143-1147 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50505135
(CHEMBL4453597)Show SMILES O[C@@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wU:15.17,1.1,(40.37,-25.74,;40.37,-27.28,;39.04,-26.5,;37.71,-27.27,;36.3,-26.63,;35.27,-27.77,;36.03,-29.11,;37.54,-28.8,;33.73,-27.77,;32.81,-26.51,;31.35,-26.98,;31.34,-28.53,;32.81,-29.01,;40.37,-28.82,;41.7,-29.6,;43.03,-28.84,;44.36,-29.61,;45.7,-28.84,;45.7,-27.29,;47.03,-26.52,;48.36,-27.29,;48.37,-28.84,;47.03,-29.61,;49.69,-26.51,;51.03,-27.28,;49.69,-24.97,;51.02,-25.73,;43.04,-27.29,;41.71,-26.52,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi & Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met... |
Bioorg Med Chem Lett 29: 1143-1147 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV |
More data for this Ligand-Target Pair | |