BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Glycine receptor subunit alpha-1/beta' and Ligand = 'BDBM50464255'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycine receptor subunit alpha-1/beta


(Homo sapiens (Human))		BDBM50464255
PNG
(CHEMBL4083687)
Show SMILES [H][C@@]12CN(C[C@]1([H])c1ccccc1N(C)C2=O)S(=O)(=O)c1ccc2OCOc2c1 |r|
Show InChI InChI=1S/C19H18N2O5S/c1-20-16-5-3-2-4-13(16)14-9-21(10-15(14)19(20)22)27(23,24)12-6-7-17-18(8-12)26-11-25-17/h2-8,14-15H,9-11H2,1H3/t14-,15-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 300n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay

Eur J Med Chem 137: 63-75 (2017)


Article DOI: 10.1016/j.ejmech.2017.05.036
BindingDB Entry DOI: 10.7270/Q2H134PC
More data for this
Ligand-Target Pair